He attended Hawken School in Gates Mills, Ohio, excelling in football, basketball, track and field and baseball.

His performance in Penn State's 1992 Fiesta Bowl victory over Tennessee on January 1, 1992, garnered him the game's offensive MVP.

That same year, McDuffie became the first player in NFL history to record at least 90 receptions and 10 punt returns in a season without a fumble.

Nearly ten years later, McDuffie would win a Medical malpractice lawsuit related to that career-ending toe injury.

[6] On May 5, 2010, Miami-Dade County, Florida jurors ordered a former Dolphins team physician, Dr. John Uribe, to pay McDuffie $11.5 million in damages.

[7] The lawsuit alleged Uribe told McDuffie he was safe to continue playing football, despite MRIs showing damage to the tendons in his toe.

[7] On September 30, 2010, Judge Michael Genden of Miami-Dade County tossed out that verdict due to the improper use of a medical manual as evidence.

He is also the founder and chairman of the Catch 81 Foundation, an organization created to raise money for children's charitable causes in the South Florida metropolitan area.