She spent two terms as the National Association of State Radio Networks' news directors' group president.

She has also been on PBS NewsHour, Meet the Press on NBC, This Week on ABC, CNN, Fox News, and MSNBC.

Christi Parsons of the Chicago Tribune said that presidential candidates take Henderson "pretty seriously" with Tommy Vietor, a spokesman for Barack Obama during his 2008 campaign, saying, "She's the voice of Iowa".

[2] In 2021, Henderson took over the role of host for the public affairs show Iowa Press from David Yepsen.

[3] Henderson was born on November 3, 1964, the day of the 1964 United States presidential election in which Lyndon B. Johnson won the presidency in a landslide;[1] her father had spent the day counting ballots as an election judge and her mother voted from her hospital room.