It is 2.75 miles (4.43 km) long and runs east–west, entirely within Malheur County.

OR 452 was established in 2003 as part of Oregon's project to assign route numbers to highways that previously were not assigned, and, as of July 2018, was unsigned.

OR 452 begins at an intersection with OR 201 at Adrian and heads east, crossing the Snake River and intersecting OR 454 on the east side of the river.

OR 452 was assigned to the Parma Spur of the Succor Creek Highway in 2003.

The entire route is in Malheur County.