3AIH10956216440ENSG00000135506ENSMUSG00000040462Q13438Q8K2C7NM_001261422NM_001261423NM_006812NM_001171026NM_177614NP_001248351NP_001248352NP_006803NP_001164497NP_808282Protein OS-9 is a protein that in humans is encoded by the OS9 gene.

[5][6][7][8][9] This gene encodes a protein that is highly expressed in osteosarcomas.

This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits.

Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

[9]