[3][4] The mall has retail anchor tenants including Macy's, Nordstrom, and Neiman Marcus, and specialty retailers such as Apple, Lucid, Microsoft, Altar'd State, Oak+Fort, Tory Burch, Allbirds, Arc'teryx, Golden Goose, Fabletics, Rhone, and Warby Parker.

On Christmas Day 1964, a single-screen movie theater operated by Balaban & Katz Corporation was opened at the Oakbrook Center near Saks Fifth Avenue.

Bonwit Teller closed their location in 1990, while I. Magnin was shuttered in January 1991, with its former site subdivided in 1994 for specialty stores, including Eddie Bauer and Tiffany & Company.

[12] On January 4, 2012, Bloomingdale's announced that it would shutter its Oakbrook Home store by March of the year.

"[15] On June 20, 2017, Sears announced that its Oakbrook Center outpost would be reconstructed to feature additional stores.

It shuttered in September 2017 and reopened on October 5, 2018, in a smaller new store format on the first level of the mall.

[18] On April 22, 2019, it was announced Sears would also shutter its location here, as part of an ongoing plan to eliminate its brick-and-mortar format.

[21] In September 2021, a three-story Restoration Hardware store opened, featuring a restaurant and winery on its top floor.

[22] By 2023, after the government lockdown, Oakbrook Center had announced several new additions, among them Joss & Main.