"Under the guidance of his elder brother, Asamoah passed the Common Entrance Examination in 1949, after primary school education.

Then, he had to undergo an interview process with the officials of the secondary school along with the other pupils from the Volta Region seeking admission.

[8] He took the O' level Latin in 1955, and proceeded to Britain in 1956 to complete the sixth form at Woolwich Polytechnic before going on admission to King's College, London University where he earned a bachelor of Laws degree (LLB) with honours in 1960.

His legal association with Reginald Bannerman started when they were both pupils in the law chambers of Edward Akufo-Addo, a renowned lawyer, on his return from England in 1960.

An example was when it fuelled speculation after the 1969 elections that he had defected to the Progress Party, led by Dr. Kofi Abrefa Busia which won massively in Ashanti and other Akan areas of Ghana.

He had, however, won a seat in the Volta Region on the ticket of the National Alliance of Liberals (NAL), led by Komla Agbeli Gbedemah, a veteran associate of Dr. Kwame Nkrumah.

The speculation was undoubtedly fuelled by some suggestions in the press that, given the Akan-versus-Ewe schism demonstrated by the results of the elections, it was advisable for Dr. Busia to appoint him to his cabinet.

Admittedly, this is also founded on the fact that he was the General Secretary of the United National Convention (UNC), led by a veteran Danquah-Busia politician, Mr. William Ofori Atta (Paa Willie), and subsequently the General Secretary of the All People's Party (APP), formed by the merger of the UNC with the Popular Front Party (PFP) in 1981, under the leadership of Mr. Victor Owusu, another Danquah-Busia stalwart.

[8] Within this period Asamoah also served as the General Secretary of the United National Convention (UNC) from 1979 to 1981 and of the All Peoples Party (APP) in 1981.

[14] Prior to leaving the foreign Affairs ministry and being appointed to serve as Attorney General of Ghana and Minister for Justice, he had acted in that role from 1993 to 1997 under Jerry Rawlings.

[16][17][18][19][20] Asamoah was a key figure and instrumental in the formation and growth of the National Democratic Congress (NDC) in 1993 ahead of the 1993 Ghanaian elections as Ghana was going back into multi party democracy.

In 2002, Asamoah replaced Rawlings as head of the opposition National Democratic Congress (NDC), beating former defense minister Alhaji Mahama Iddrisu by just 2 votes.

Obed Asamoah's family connection with Ejisu continues in exchanges of visits and attendance at funerals by both sides.

[9] He is also the author The Political History of Ghana (1950-2013) The Experience of a Non-Conformist, which he gives an account of his life and struggles within the Gold Coast through colonial rule and fight for independence and the future rivalry between the Convention Peoples Party (CPP) of Dr. Kwame Nkrumah and the United Gold Coast Convention (UGCC) led by Dr. Danquah and other relevant events in the Ghana's history [8]