Upon learning their friend Kenny has gone missing, Josh, Stan, Shannon, and Ashley set out to find him.

While searching the campus, they are attacked by photosensitive monsters that can be weakened with flashlights and killed by direct sunlight.

Along the way, the students become exposed to the spores while Herbert is killed by Professor Walden, who seeks to cure himself of his infection.

Upon seeing this, Herbert's brother Leonard grows enraged, kills Walden, and mutates into a large, monstrous form, only to be defeated by the students.

Some critics, including X-Play, have stated that this was the only redeeming quality, and mocked id's Doom 3 for not implementing such a concept.

The franchise was abruptly halted due to the closure of Hydravision Entertainment, who had intended to do a sequel and possibly a prequel.