Shannon and Kenny are now enrolled in the nearby Fallcreek University, while Stan is reforming his life as a delivery truck driver.

As the story begins, a new drug created from a strange flower is quickly spreading its influence over the University's populace.

Soon enough, a small group of students, along with the Leafmore High survivors have to face a horde of mutants and try to stay alive.

Then the whole group reunites in the hospital's east ground floor, where they make a chemical dynamite to destroy a wall and get to the parking lot.

Stan, having responded to Kenny's call before mutating, meets with the surviving group and drives them away, until he crashes off and falls into a dam.

Whilst they find a place to take refuge, Amy and Sven explore and are ambushed by a man with a disfigured face carrying a chainsaw.

The huge tree was actually the mutated remains of Leonard Friedman (from Obscure) whilst the disfigured man is his son, Jedidiah.

On their way, they stump upon the museum of the Delta Theta Gamma within Fallcreek and discover that they are responsible for covering up the Leaftmore incident and involve in the Fredman's experiment with the Mortifilla.

Stan asks Shannon what to do next; she replies that she will continue on and cut all family ties as well as stopping the Delta Theta Gamma organization.