[1] Established by Osagyefo Dr. Kwame Nkrumah in 1965 as Government Secondary Technical School, which was an all boys institution offering Science and Technical Programs only, the first of its kind in the northern sector of Ghana.
The school in 2019 reached the quarter-finals of the National Science and Maths Quiz Competition after beating St Francis Xavier Minor Seminary and Krobo Girls SHS.
Masters Kojo Daniel Eshun and Lawrence Adjei were the proud contestants for that day.
Obuasi Senior High Technical School has won the Ashanti regional Milo soccer competition in 2005 and 2015.
[3] In the Zonal Inter Colleges Athletics competition, they have won several times[vague][4][failed verification] Students of the school were claimed to have created 'a touchless bin' in the fight against COVID-19.