Ochirtu Setsen Khan (died 1676 or 1677) was a prominent leader of the Khoshut tribe and a ruler of the Four Oirats Confederation.
Ochirtu Setsen Khan's political activities began in 1637 after the Oirat military forces defeated and eliminated Tsogt Taij of the Khalkha in the Qinghai region.
In 1640, he participated in a gathering of 28 Khalkha and Oirat nobles and religious figures in the Tarvagatai Mountains, where they ratified the Great Code of Forty and Four to unite against foreign threats.
Between 1645 and 1646, a conflict arose between Ochirtu Setsen Khan and his younger brother, Ablai Taishi, over wealth, subjects, and pasturelands.
Following Zaya Pandita’s death, Ochirtu Setsen Khan personally traveled to Lhasa to request the recognition of his reincarnation and bring him back to Oirat lands.