Ocythoe tuberculata is found in warm and temperate seas, especially in the Northern Hemisphere, such as the North Pacific Ocean off California.

[3] In captivity, two specimens were observed controlling their buoyancy and shooting water "forwards, upwards, sideways, and backwards" from the upper channel of the mantle cavity.

[3] The entire swimbladder structure rests on the "visceral mass" and connects to the mantle cavity.

[4] This structure contains the spermatophores and is dislodged and detached in the mantle of the female during mating and remains for an extended period of time for fertilization.

[4] Young females and mature males have been observed residing inside salps, although little is known about this relationship.

O. tuberculata have been well known for inhabiting mainly northern hemisphere waters, typically in the Mediterranean Sea, as well as the eastern and western parts of the North Atlantic.

Tuberculate pelagic octopuses is said to be viviparous, meaning their offspring develop with in the body of the parent.