Oder-Spree is a Kreis (district) in the eastern part of Brandenburg, Germany.

Neighboring are (from north clockwise) the district Märkisch-Oderland, the district-free city Frankfurt (Oder), Poland, the districts Spree-Neiße and Dahme-Spreewald, and the Bundesland Berlin.

In the top left quarter is the coat of arms of the Bishops of Lebus, who had their seat in Fürstenwalde.

The second quarter shows the checkered bar of the Cistercian Order as the symbol of the Abbey of Neuzelle, who until 1817 owned most of the territory which later became the district Eisenhüttenstadt.

The capital of the district is Beeskow, but Fürstenwalde is the biggest town, with a population of 31,000 people.