She is known for various roles in film and television, including as Dr. Jessica Adams in the Fox medical drama series House, Beth McIntyre in the monster film Cloverfield, Aubrey Diaz in the ABC drama series October Road, Samantha Arias / Reign in Supergirl, and Nola Longshadow in Banshee.

Odette Juliette Yustman was born on May 10, 1985,[4] in Los Angeles County, California, to a Colombian father and a Cuban mother.

[12] Annable played Melanie Garcia on the comedy Breaking In as a series regular in its first season, appearing as a guest star thereafter.

[13][14] She joined the TV series House as Dr. Jessica Adams,[15] and remained on the show until the finale in May 2012.

In March 2014, Annable was cast as Trudy Cooper in the ABC series The Astronaut Wives Club.