It seated 2,500 for indoor soccer, football or lacrosse, and up to 5,500 for boxing, MMA/UFC, wrestling, and concerts.

In 2010, the Odeum became the home to the Chicago Cardinals of the Continental Indoor Football League.

Also in 2010 the Chicago Riot of the Major Indoor Soccer League began play at the Odeum Expo Center.

In 2014, the Chicago Blitz professional indoor football team began play at the Odeum in the CIFL.

In January 2022, it was announced that the Odeum would be sold and permanently closed at the end of May 2022.