Odstock is a village and civil parish 3 miles (4.8 km) south of Salisbury in Wiltshire, England.

The Domesday Book in 1086 divided the Chalke Valley into eight manors, Chelke (Chalke), Eblesborne (Ebbesbourne Wake), Fifehide (Fifield Bavant), Cumbe (Coombe Bissett), Humitone (Homington), Odestoche (Odstock), Stradford (Stratford Tony) and Trow (circa Alvediston and Tollard Royal).

[8] At the church is the grave of Joshua Scamp who, to protect his daughter, took the blame for his son-in-law's theft of a horse, and was hanged.

[13] Odstock Hospital was built in 1942 0.8 miles (1.3 km) north of the village, in the parish of Britford.

With the creation of the National Health Service in 1948, the hospital was selected to house a new regional Plastic and Oral Surgery Centre providing burns and (since 1984) spinal care for patients in five counties.