The station was opened in 1871 at a location that was then on the northern edge of the town of Oebisfelde during the construction of the Berlin–Lehrte railway, which connected Berlin with Hanover.

After 1880, Oebisfelde became the location of a railway workshop, which developed into a locomotive depot (Bahnbetriebswerk).

[4] The population of Oebisfelde increases substantially and the railway was the town’s main employer.

An overpass was built at the western end of the station in 1910 because of the dense rail traffic.

In the last years of the Second World War, the station was hit by several bombs, with freight trains being targeted in particular.

With the establishment of the Inner German border just to the west of Oebisfelde, operations to Wittingen were stopped in August 1945.

The light railway station at Oebisfelde was renamed Oebisfelde-Nord and it was now only used for freight traffic.

During the Berlin Blockade, cross-border traffic in Oebisfelde came to a halt from 24 June to 9 September 1948.

[4] In 1952, a five kilometre-wide exclusion zone was established at the inner German border to prevent the escape of citizens from East Germany (GDR).

The border crossing facilities were located immediately south of track 1 and west of the station building .

Only when the person in charge of the Border Troops gave the order could the catch point be set to allow exit to West Germany.

Immediately west of the station there was a collision between an express train and a tank car on 27 July 1991.

For the construction of high-speed railway, the northern exit of the line to Salzwedel had to be moved.