The strip initially featured four main cartoon characters whose outlook on life was stereotypical: Stan the gay man, Vera the bull-dyke, Winston the nerd, and Victor the moron.
The cast has since expanded to include additional characters such as Fundie, Kay, and Reiki Master.
Despite the strip's frequent references to Pagan and Wiccan sub-culture, it has a substantial Christian following as well as a Neopagan audience, and even among Unitarian Universalists.
The following year, a strip entitled "Finale" was posted along with a note from the creator indicating that he had decided to cease creating the Oh My Gods!
also features simple reverse font slogans which are supposed to resemble religious bumper stickers and special remembrances of the deaths of Shivian Balaris's father and Pope John Paul II, and the September 11, 2001 attacks.
Characters have died in the course of the story and remained so, in a departure from the convention of comic strip comedy.
This fantastic aspect is embellished by the appearance of such characters as the Pope, a Clown for Christ, and Unitarian Universalists who are depicted as Borg.
Additionally, they have been shown great surprise when Shivian made a change to the style of the comic such as the introduction of color, legs, or fleshed out backgrounds.
These volumes are the first time that years six and seven of the comic have been made available in book form:[12] It has won the Golden Web Award for 2003–2004, was a UserFriendly.org Link of the Day and has received reviews from the Shadow Witch Web and Sequential Tart.