It is the tenth longest state route in Ohio [citation needed].

After leaving Chauncey, it bypasses Millfield, Ohio, then enters Trimble Township and passes through Redtown, Jacksonville, Trimble, Glouster, Palos, then passes by the dam side of Burr Oak State Park and passes Burr Oak.

For much of its length in Athens and Perry Counties, the highway is paralleled by a line of the Norfolk Southern Railway.

Since then, US-33 was rebuilt as a four-lane divided highway, and is across the Hocking River now from Chauncey.

The former section of US-33 was divided between Ohio State Route 682, to the west, and Ohio State Route 13, to the east, slightly extending both roadways.