U.S. Route 250 (US 250) is a United States Numbered Highway that runs from Sandusky, Ohio to Richmond, Virginia.

This part of the route carries much traffic connecting to the Ohio Turnpike, and during the summer, people bound for Cedar Point.

Much of this section of the route is rural and two-lane, but it carries a high level of truck and regular traffic.

US 250 continues southeast until it meets SR 60, and the two routes enter Savannah on North Main Street and pass straight through town.

On Dover Road, US 250 follows a two-lane alignment as it passes through mostly open fields on its path to Strasburg.

The route forms the main streets of several communities as it passes through them, such as Apple Creek, Mount Eaton, and Wilmot.

This densely populated stretch of US 250 in Strasburg has been proposed for a bypass, but the project has not been selected for further work as of 2008.

This route is generally of good quality (albeit without shoulders), although ODOT is studying replacement or upgrade through its Macro-Corridors Project.

After it passes through Harrisville, the road becomes less curvy but is fronted densely with homes for almost the remainder of its route within the state, save the forest at its south end, where it features another hairpin curve.

To resolve these issues, the Ohio Department of Transportation is developing plans to construct a Super 2 replacement for this route.