Shortly after leaving Bellaire, the route passes through a large Cut as the creek bends to the south briefly.

As the route heads west along the creek, SR 149 passes through several unincorporated communities including Neffs and Glencoe.

Prior to here, SR 149 traveled through a densely wooded valley, but now the route heads through more farmland with rolling terrain.

East of Flushing, SR 149 heads northeast for the last 2 miles (3.2 km) of the route through Belmont County.

[4] The route is lightly traveled; the busiest section of the road as measured by the Ohio Department of Transportation (ODOT) is within the SR 7 interchange in Bellaire with an AADT of 9,560.

[10] In 2010, ODOT completed a 1.4-mile-long (2.3 km) relocation of SR 149 to move the state highway off of the local streets in Bellaire.