The route runs through generally rural sections of southern Mahoning County, and serves East Palestine in extreme northeast Columbiana County.

The route connects quite a few unincorporated villages in southern Mahoning County as it passes through.

It was originally routed from North Lima to East Palestine.

[2][3] In 1937 the route was extended to Beloit along previous unnumbered road.

[4][5] The highway was rerouted from Unity to Pennsylvania state line along previous Route 14, in 1946.