Established in the late 1930s, State Route 626 is a two-lane highway that primarily serves local traffic in the southeastern Mahoning County municipality of Beaver Township.

Running northwesterly from that intersection, the two-lane state route passes a number of houses, with woods abutting the roadway along the way.

At Miley Road, the highway turns to the north-northwest, and passes just to the west of the partial I-680 interchange off of the Ohio Turnpike (I-76).

The route passes by a couple of commercial buildings as it departs the intersection, then travels amidst a blend of wooded terrain and open fields with scattered homes along the way.

Finally, SR 626 passes a couple of commercial businesses as curves to the west, passes a former alignment of the route (when it ended at a five-point signalized intersection), and ends approximately two miles (3.2 km) south of Boardman where it meets SR 7 in the community of Woodworth.