The southern terminus of the highway is at a diamond interchange with the U.S. Route 33 (US 33) expressway approximately one mile (1.6 km) southeast of the village of Zanesfield.

Its northern terminus is at a Y-intersection with SR 31 just south of the city limits of Kenton.

SR 292 travels through the northeastern quadrant of Logan County and the southern portion of Hardin County.

[2] Certified in 1932, SR 292 was originally a spur route that traveled from Ridgeway to Mount Victory via its current routing from Ridgeway up to the current SR 273 junction, and SR 273 from that point east to SR 31 in Mount Victory.

[5][6] By 1997, when US 33 was converted to a four-lane expressway through southeastern Logan County, SR 292 was extended again, taking over several miles of the U.S. highway's former two-lane alignment, as far as a point in southern Jefferson Township between Zanesfield and Valley Hi, where SR 292 arrived at what is currently its southern terminus at a diamond interchange with the new expressway.