[2] Both Drexel (a census-designated place) and the intersection straddle the border between Trotwood and Montgomery County's Jefferson Township.

The roadway carrying SR 49 continues southward (signed "east") from this intersection as US 35 (designated "C. J. McLin Jr. Parkway"), a limited-access expressway into downtown Dayton.

(Westbound US 35 proceeds along West Third Street) SR 49 continues north from US 35 through Trotwood along an expressway locally called the "Northwest Connector" or the "Trotwood Connector",[3][4] then turns onto Salem Avenue, which crosses into Clayton.

SR 49 then exits from I-70 at ramps passing from Clayton into Clay Township, Montgomery County.

The route then continues north to Greenville, Fort Recovery, Willshire, Convoy, Payne, Antwerp, Hicksville, Edgerton and Edon.

[2] A portion of SR 49 in Montgomery County has been designated the "Joseph G. LaPointe Jr. Memorial Highway", in honor of the United States Army medic who posthumously received the Medal of Honor for his actions during the Vietnam War.

It traveled west along First Street and Monument Avenue, crossing under I-75, and over the Great Miami River.

[19][18][20] The old segment of SR 49 along Salem Avenue was finally deleted from the state highway system in the summer of 2004.