The highway passes through industrial properties while paralleling CSX railroad tracks.

[4][5][6] After paralleling the tracks the route crosses them and enters downtown Wapakoneta.

The street passes allow the south side of the Auglaize County Court House.

[5][6] Here, SR 501 has its highest traffic counts; within the 2011 ODOT survey, the road is listed with an average annual daily traffic (AADT) of 9,450 vehicles on a section of highway over the river.

[5][6] The highway enters Hume and crosses the Western Ohio Line of the R.J. Corman Railroad.

[7] After Hume, the route passes through farmland and a group of house before ending at an intersection with SR 117.