State Route 516 (SR 516) is a two-lane east-west state highway that runs entirely within Tuscarawas County in eastern Ohio.

Its eastern terminus is at a signalized intersection with State Route 39 in Dover, just one block west of the Interstate 77/U.S.

Created in the late 1930s, State Route 516 serves primarily rural portions of northwestern Tuscarawas County including Winfield, Ohio.

Established in 1937 along the Dundee-to-Dover path that it occupies today, State Route 516 has not seen any major changes to its routing since its designation.

[2][3] The entire route is in Tuscarawas County.