The route passes through primarily rural portions of Washington, Morgan, Perry, and Muskingum counties, connecting unincorporated villages along the way.

The two routes head west into Perry County before SR 555 breaks off and travels north.

At the city limits, CR 6 ends and SR 555 is its own route again (though within any incorporated towns, state highways are maintained by the municipality[4]).

[6] The next highest traffic count along the route was at a station just south of the SR 719 intersection; its AADT in 2012 was only about 4,500 vehicles.

[7][8][9] Each year, since 2011, Saint John's Lutheran Church in Stovertown (right on 555 just outside Zanesville) holds the "Triple Nickel Country Cruise-In" the Saturday before Father's Day in June.

[11][12] Originally, SR 555 crossed the Muskingum River on the Five Mile Bridge connecting Brush Creek and Wayne Townships.

In 1975, the Ohio Department of Transportation (ODOT) proposed a realignment of SR 555 along the west side of the river from Brush Creek Township to South Zanesville utilizing Muskingum County Road 6.