Heading south from Vermilion, SR 60 traverses rural North Central Ohio while connecting Vermilion, New London, Ashland, and Loudonville.

It closely parallels the Muskingum River for the remainder of its journey to Marietta except for an eleven-mile (18 km) stretch in Morgan County where it moves inland to avoid bends in the river.

Markers for SR 60 are not posted south of the Greene Street/3rd Street intersection in Marietta.

In order to eliminate a numerical duplication with an Interstate highway in Ohio having the same number, Interstate 77, SR 77 was renumbered in part as SR 60.

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