The highway's southern terminus is at SR 2 on the boundary between Williams and Defiance Counties, approximately 3.25 miles (5.23 km) southwest of Bryan.

The northern terminus of SR 576 is at the Michigan state line about 5.50 miles (8.85 km) northwest of Pioneer, where the roadway continuing into Hillsdale County, Michigan is county-maintained Hillsdale Road.

No segment of this state highway is included within the National Highway System, a network of routes determined to be the most important for the economy, mobility and defense of the nation.

[2][3] By 1957, SR 576 took on the shape that it has today, when it was extended northerly out of Montpelier concurrent with US 20A to US 20, then west along US 20 a short distance, and north over the former SR 571 to its present northern terminus at the Michigan state line.

Media related to Ohio State Route 576 at Wikimedia Commons