The short SR 723 commences at I-70's exit 176, a trumpet interchange in Guernsey County's Cambridge Township.

Heading north from I-70 as a four-lane highway, SR 723 passes over the CSX railway and crosses the city limits of Cambridge.

A short distance later, SR 723 comes to an end as it meets US 22 and US 40 at a signalized T-intersection.

[2] SR 723 is not considered a part of the National Highway System.

[4] For the first few years of its existence, SR 723 served as the western end of a section of I-70 that was complete.