The western terminus of SR 752 is at a signalized T-intersection with US 23 on the north edge of South Bloomfield, and its eastern terminus is at SR 674 about 7 miles (11 km) east of Ashville on the Pickaway-Fairfield County Line.

This two-lane state highway, which runs through the northeastern portion of Pickaway County, is becoming more highly traveled in recent years, as subdivisions are being constructed at a rapid rate in the Teays Valley Local School District.

The entirety of SR 752 is located in the northeastern quadrant of Pickaway County.

[2] SR 752 was designated in 1937, following the alignment that it occupies to this day.

No changes of major significance have taken place to this state route since its inception.