This segment of State Route 82 is very heavily traveled, and intersects with four interstate highways.

After passing through the northern tier of Portage County, State Route 82 crosses central Trumbull County, becoming a freeway for ten miles (16 km) along with State Route 5 as it bypasses the city of Warren.

East of Warren, the route continues as a 4-lane divided highway, with level intersections at most secondary roads and interchanges with most other state highways, including a modified cloverleaf interchange with State Route 11.

The former alignment of State Route 82 in Trumbull followed Market Street through Warren (concurrent with State Route 5 to Elm Road), and then continued east on what is now Warren-Sharon Road through Howland, Vienna, and Brookfield Center.

In 2012, three men were sentenced to prison for a plot to blow up the Route 82 bridge in Cuyahoga Valley National Park.