Its southern terminus is at U.S. Route 30 (US 30) in East Liverpool at the West Virginia state line on the Jennings Randolph Bridge over the Ohio River from that state's northern panhandle; its northern terminus is at SR 531 in Ashtabula.

The highest traffic count is at I-80 near Austintown, where 38,360 vehicles travel the highway on average each day.

The highway travels north to near Leetonia, where it meets SR 344 at a diamond interchange.

The forests slowly change into farmland, as it passes under SR 14 and into Mahoning County.

[2][5] In Mahoning County, the route becomes part of the eastern city limits of Canfield, meeting US 224 at a parclo interchange.

The route then enters Ashtabula County, and travels in a straight line, passing through US 322, a rest area, US 6, and SR 307.

It ends at SR 531, part of the Lake Erie Circle Tour, at a pair of stop signs.

[9][10][11] In 2000, construction began for the King Graves Road interchange,[12] which opened a year later.

[1] The section in Ashtabula County was also designated as the "Marine Private Henry Kalinowski Memorial Highway" on April 7, 2009.

[16] Around 2002, the section in East Liverpool, starting from Newell Street, and ending at the state line, was designated as the "Lou Holtz Freeway".

A tanker truck spilled methyl alcohol onto SR 11 northbound, in Fairfield Township.