SR 88 then continues northeast, crossing over Interstate 80 and the Ohio Turnpike, before turning due north as it enters Garrettsville.

The route continues northward, entering Geauga County, becoming McCall Road here, and intersects US 422 in Parkman; this is also the southern termini of State Routes 168 and 528, which overlap SR 88 (first as Main Street, and then Madison Road).

About 1 mile (1.6 km) north of Parkman, SR 88 leaves the concurrency and continues due east as Nash Road, and then becomes Greenville Road in Trumbull County.

About 1+1⁄2 miles (2.4 km) later, SR 88 leaves the concurrency and continues east as Greenville Road to its last intersection at SR 7 in Vernon before its eastern terminus at the Pennsylvania state line, where Pennsylvania Route 358 (Vernon Road) continues east.

[6][7] The section of road between SR 7 and the Pennsylvania state line was paved in 1933.