Pennsylvania Route 358 (PA 358) is located in Western Pennsylvania, running from the Ohio state line 6 miles (9.7 km) west of Greenville to Sandy Lake in Mercer County.

Heading east from the Ohio state line in Mercer County, PA 358 travels through the village of Maysville about 3.4 miles (5.5 km) from the state line.

In 1928, PA 358 was originally signed from the Ohio state line to Greenville.

The Greenville-to-Sandy Lake alignment was originally signed PA 846 through 1936.

The eastern terminus was moved from Greenville to its current location in 1936.