The location was in territory assigned to the Creek and Seminole people when removal of tribes from the southeastern United States began in 1830.

The site of the future town of Okarche was just inside the eastern border of the Cheyenne and Arapaho reservation.

The Chicago, Kansas and Nebraska Railway was given a 100-foot (30 m) right of way through the territory and authorized to take additional right of way for stations every 10 miles (16 km) of track.

Construction proceeded southward from Caldwell, Kansas, and was completed to Pond Creek by April 1889 and to El Reno in January 1890.

The Southern Arapaho and Cheyenne Native American tribes had been relocated to Oklahoma from the northern Great Plains in the late 19th century.

[10] Catholic and Lutheran churches with schools were established as immigrants sought to keep faith and customs from the old country alive in their new home.

[11] Okarche now has four-lane divided highway access to neighboring communities, including the Oklahoma City metro area.

According to the United States Census Bureau, Okarche has a total area of 1.9 square miles (4.9 km2), of which 1.6 acres (6,662 m2), or 0.14%, is water.

In 2009, Food Network's program, Guy Fieri's Diners, Drive-Ins and Dives, visited Eischen's, and the bar was featured on the television show.

[17] Major employers include Nortek, formerly Temtrol, a manufacturer of air handling units, coils and fans; and OEM Systems, a firm specializing in custom fitting commercial vehicles and fuel conversion of vehicles to compressed natural gas.