[10] In 2015, Markarova initiated the creation of E-data (e-data.gov.ua), the largest open data portal in the public finance sector, which now includes modules spending.gov.ua, openbudget.gov.ua and proifi.gov.ua.

In addition to her duties as First Deputy Minister of Finance, she was also appointed the Commissioner for Investment on 8 August 2016, a position she held until her dismissal from the role on 10 January 2019.

[16] After her dismissal Markarova returned to the private sector and her work on the supervisory board of the Kyiv-Mohyla Academy.

[17] On 25 February 2021, Ukrainian President Volodymyr Zelenskyy appointed Markarova Ambassador of Ukraine to the United States.

[2] Immediately after her appointment, Markarova said that her main priorities for the new position were expanding "cooperation with the Joseph Biden administration and political dialogue based on their broad bipartisan support"[18] and "maximum assistance to the development of Ukrainian companies in the United States and attracting American companies to Ukraine".

[19] On September 25, 2024, the Speaker of the U.S. House of Representatives, Mike Johnson, demanded that Ukraine remove Marakova as Ambassador to the United States after Zelenskyy visited an ammunition plant in Scranton, Pennsylvania, and appeared with several notable Democrats.