She graduated Class of 1893 from the Snell Seminary in Oakland, where she was celebrated for her ability at dramatic recitation, and in 1894 attended the Emerson School of Oratory in Boston, Massachusetts after this beginning her professional career.

[1] Humphrey toured in stage companies in Australia, New Zealand,[2] and Great Britain, in The Empress,[3] The Prodigal Son (1906),[4] The Little Gray Lady (1906),[5] The Scarlet Pimpernel, The Second Mrs. Tanqueray, The Thief, and Another Woman's Window (1918),[6] among others.

[7] She appeared in three silent films: Under the Crescent (1915, now lost; a highly fictionalized, serialized version of Humphrey's own story,[8] written by Nell Shipman).

[7] Their 1911 marriage in a London registrar's office was witnessed by American Vice-consul Richard Westacott (1849–1922) and the Count de Nevers.

[16] Late in life, she was living in an apartment in New York,[17] her fortune lost or withheld by the Prince's relatives.