Olayuk Akesuk (born 1965) is a politician from Kinngait, Nunavut, Canada.
Akesuk was the Member of the Legislative Assembly (MLA) for the electoral district of South Baffin from 1999 to 2008, having won the seat in the 1999 Nunavut election.
In the first elections held in the newly created territory of Nunavut in 1999, Akesuk defeated Goo Arlooktoo, who had been deputy premier of the Northwest Territories, from which Nunavut had been split off.
This was considered one of the biggest upsets of the election, as many people had expected Arlooktoo to become premier of Nunavut.
On 10 September 2008, Akesuk was appointed Health Minister after Leona Aglukkaq stepped down to run in the 2008 Canadian federal election for the Conservative Party.