Melbourne Street is the main commercial area of the second-largest of the three grids that comprise North Adelaide.

[3] Melbourne Street is bracketed by Brougham Place and Mann Road and runs in a north-easterly direction.

Ervin Gallery's 2021 Salon des Refusés exhibition (the alternative Archibald and Wynne Prize selections),[6][7] and Australian Toys 1880–1965: The Luke Jones Collection (2024)[8] Other attractions and events taking place in Melbourne Street, including:[9] Two of the well-known buildings on the street are The Lion Hotel, which was built as part of a brewery and is now a fashionable public house, and Buffalo Cottage, which was built in 1851.

[12] In 1884 Beaglehole organised formation of the Lion Brewing and Malting Company and was elected chairman of directors.

Beaglehole, along with Johnston senior and his sons James and Andrew thus secured the brewing, hotel, and property rights of the company, issuing 75,000 shares of one pound each.

[21] During the COVID-19 pandemic in 2020, the hotel was forced to close for some months, and was afterwards purchased by the Duxton Pubs Group,[22] who were still the owners in December 2023.