[6][7] In terms of its sleep inducing effects, it is speculated that oleamide interacts with multiple neurotransmitter systems.

[11] At larger doses oleamide can lower the body temperature of mice by about 2 degrees, with the effect lasting about two hours.

[13] It has been postulated that some effects of oleamide are caused by increased concentrations of anandamide brought about through the inhibition of FAAH.

[9] It has been claimed that oleamide increases the activity of choline acetyltransferase, an enzyme that is critical in the production of acetylcholine.

[15] Oleamide was found to be leaching out of polypropylene plastics in laboratory experiments, affecting experimental results.