Matytsin started his table tennis career in 1975 in Moscow, Russia and played for the USSR university sports society "Burevestnik".

[4] He later headed the Russian State Academy of Physical Education table tennis team, which won both the 1988 and 1990 USSR Universiades.

[citation needed] Matytsin worked as a lecturer for the Russian State University of Physical Education, Sport, Youth and Tourism (from 1986-to 1996) and later went on to develop his career within the institution.

[5] The Russian Student Sport Union played a key part in organising the Summer Universiade, which was a great success.

[citation needed] Following Kazan's success, Matytsin became one of the founders of the FISU International Educational Centre in the Volga Region State Academy of Physical Culture, Sport and Tourism.

Matytsin also played a key role in Krasnoyarsk's nomination as a candidate for the winter Universiade in 2019, with the city eventually chosen by FISU 9 November 2013.

[citation needed] Since 2014, Matytsin's work as leader of his national university sports federation (NUSF) received recognition from both the IOC and FISU.

The strategy is dictated by FISU's vision, which is "to create a world where university sport has positively shaped the majority of leaders in society".

[18] In anticipation of Matytsin's election Dmitry Svishchev resigned from his position as Chairman of the State Duma Committee on Physical Culture and Sport in late July 2024.

[19] On September 16, 2024, Matytsin, along with fellow freshmen and former Mikhail Mishustin's Cabinet member Viktoria Abramchenko and Nikolay Shulginov, was unanimously admitted to the United Russia faction in the State Duma.