Hoping to become an agronomy teacher, upon completing her high school studies, she attended biology lectures with Professor Tarkhnishvili.

[2] At the time, there were few opportunities for university study for women in the Russian Empire, and Guramishvili dreamed of going abroad to further her education in Switzerland.

[2] Guramishvili, one of the first Georgian women to study abroad, became involved in the student movement and became active with other Georgian women students like Fefo Eliozishvili, Ekaterine Melikishvili, Pelagia Natsvlishvili, Ekaterine "Kato" Japaridze (sister of Agrippina Japaridze), Olimpiada Nikoladze and Mariam Tsereteli.

[4] Instead, Guramishvili left with Niko to study at the University of Geneva,[2] where members of the Yoke became more closely aligned with radical philosophies the intelligentsia in Western Europe and Russia.

[2][5] Niko left Geneva and went to Paris, where he married a Polish woman, Bogumila Zemianskaia (also Bogumiła Ziemiańska), who had lived for a while in his hometown, Kutaisi.

In his memoir, revolutionary figure, Nikolai Morozov, wrote that Kato Nikoladze, Mashiko Tsereteli and Guramishvili were to be found as a trio at almost every gathering of Geneva's international community or French communists.

After completing her degree in pedagogy,[3] Guramishvili briefly lived in Saint Petersburg, but was expelled from Russia for her involvement with Nikolay Mikhaylovsky and the Narodniks.

[7] After teaching at the gymnasium for five years, Guramishvili left in 1880 and accompanied Niko when he was arrested and exiled to Stavropol, though he did not refrain from his radical publishing activities.

[6] Niko and Zemianskaia were formally separated in the early summer of 1883, and on 29 July, he and Guramishvili married at the Kashveti Church in Tiflis.

[5] By 1916,[Notes 2] Niko was working in Saint Petersburg, having taken a post on the board of Russkaia volia (Russian Liberty), a leading left-leaning journal.

[17] On 5 September, Rusudan left newly renamed Petrograd with her son to return to the family home in Didi Jikhaishi and avoid the turmoil of the revolution.

[13] Tamar, an academic, physiologist and one of the first women in Georgia to participate in international sporting events, married one of Giorgi's colleagues, Nikoloz Muskhelishvili.