Before becoming assistant professor at the University of California in Santa Barbara in 1988, Günther worked as a post-doc at the International Computer Science Institute (ICSI).

From 1989 till 1993 he held a leading position at FAW Ulm (Forschungsinstitut für anwendungsorientierte Wissensverarbeitung).

Günther has conducted research projects in the areas of enterprise information systems, IT strategy, security and privacy, digital asset management, collaborative software, database management, as well as geographic and environmental information systems.

He has held visiting faculty positions at the European School of Management and Technology in Berlin, the École Nationale Supérieure des Télécommunications and the Pôle universitaire Léonard-de-Vinci in Paris, the University of California at Berkeley, and the University of Cape Town.

He was chairman of the board of Poptel AG, Germany's first voice-over-IP company, and chief technology officer of Teamtoolz, Inc., a San Francisco-based cloud service provider for the marketing and advertising industry.