After leaving Formula One, Grouillard raced in the CART PPG World Series, competing in the Indianapolis 500 for which he did not qualify but showed consistency.

In 1983, Grouillard went into French F3 and drove for the ORECA team racing a Martini Mk39 Alfa Romeo to finish 4th scoring 33 points.

For 1985, Grouillard competed in the inaugural season of F3000 spending the year mostly confined to qualifying in the midfield but delivered good races along with reliability.

He started from 17th at his home race at the French Grand Prix and drove to 6th, despite having issues with the tyres and gearbox, scoring his only World Championship point.

In qualifying for the Belgian Grand Prix at Spa, Grouillard impeded the Lotus of Nelson Piquet by staying on the racing line whilst the Brazilian was on his last flying lap.

[3] During his last 2–3 seasons in Formula One, René Arnoux had gained the reputation of being a blocker, a driver who rarely used his mirrors and regularly held up others both in qualifying and races.

During the race, Grouillard was hit by Riccardo Patrese's Williams at the second corner and eventually retired after a second collision with the Swiss driver Gregor Foitek.

Grouillard finished 16th at Spa with retirements at Monza and Jerez with wheel bearing problems that plagued the Frenchman throughout the year.

At the season ending Australian Grand Prix in Adelaide, Grouillard finished 13th and again held up Nigel Mansell during the race which led to the British driver shaking his fist at the Frenchman in front of the on-board camera.

A change of fortune did come at Mexico, where he qualified his season-best 10th, but was forced to start from the pit lane after suffering from mechanical problems in the car, and he eventually succumbed to an engine failure after 14 laps.

For the race, Grouillard was the slowest in pre-qualifying behind new team-mate Fabrizio Barbazza, with the AGS team folding before the pair could get to Japan and Australia.

After the 500, Grouillard showed consistency and had a reliable car finishing in eight out of 11 events with only one mechanical retirement at Michigan and a collision with Arie Luyendyk at Vancouver.

[5] Unable to make a success in CART, he returned to Europe in 1994 and raced sports cars in the BPR Global GT series.

He had previous experience in 1990 where he and co-drivers Martin Donnelly and Kenny Acheson qualified 5th at Le Mans but gearbox problems prevented the trio from starting.

Throughout the season, he also competed in other events such as the Daytona 24 Hours with Derek Hill and Gildo Pastor Pallanca with a transmission problem forcing the trio out.

For that year's Le Mans race, Grouillard drove in a Courage Compétition C36 Porsche with Mario Andretti and his son Michael, but retired after fifteen and a half hours.

[5] He returned to the race in 1998, driving a La Filiere Courage C36 Porsche with Henri Pescarolo and Franck Montagny managing to finish 16th.

[5] For 2000, Grouillard raced in the American Le Mans Series driving a Courage C52 Peugeot with Sébastien Bourdais coming 6th at Silverstone and entered the Nurburgring round but did not take part in practice.