Grosjean moved to the IndyCar Series in 2021 with Dale Coyne, achieving his maiden pole position and podium at the Grand Prix of Indianapolis.

In a one-off appearance in the British Formula Three Championship he started on pole position for both races at Pau, won both, and set the fastest lap in each.

[4] He stayed in the Formula 3 Euro Series for 2007 but moved to the ASM team, for which Jamie Green, Lewis Hamilton, and Paul di Resta won the previous three titles.

[4] Sébastien Buemi led the championship in the early stages but Grosjean moved ahead with a victory in the ninth race of the season at Mugello.

[8] Grosjean drove for ART in the inaugural GP2 Asia Series season alongside Stephen Jelley, winning both races of the first round of the championship.

He initially continued in the test driver role at Renault for 2009 but took over Piquet's seat in the wake of the Crashgate controversy from the European Grand Prix onwards.

At the Italian Grand Prix, Grosjean qualified a career-best 12th, but made a poor start, damaged his car with contact at the first corner, spun on the second lap, and finished 15th.

At the Japanese Grand Prix, Grosjean qualified 18th, which he blamed on rain throughout practice preventing him from fully learning the demanding Suzuka Circuit, which he had never driven on before.

He qualified 13th in his repaired car, gained positions at the start, but then slipped back down to 13th after complaining of grip and tyre temperature problems, his best result of the season.

[19] In June 2010, Grosjean made his debut in the famous Le Mans 24 Hours endurance race, sharing a Ford GT1 with Mutsch and Jonathan Hirschi.

[21] After dominating practice and taking pole position, he won the feature race before finishing second to Carlos Iaconelli in the sprint event.

He lost the championship lead to Giedo van der Garde, after the second round of the series, after an event which was hampered by disqualification due to a technical infringement,[26] but regained it again the following week at Monaco, scoring points in both races despite starting from last place on the grid.

After scoring four further wins as part of a mid-season run that included six consecutive podium finishes, he pulled clear of his pursuers and clinched the championship at the penultimate round at Spa-Francorchamps.

At the start of 2011, Grosjean returned to the newly branded Lotus Renault GP team as one of five test drivers along with Bruno Senna, Ho-Pin Tung, Jan Charouz and Fairuz Fauzy.

[33] In Spain Grosjean started third, finished fourth and set his first fastest lap in Formula One; the first for a French driver since Alesi at the 1996 Monaco Grand Prix.

At the German Grand Prix, Grosjean started nineteenth due to a gearbox penalty and finished eighteenth after picking up a puncture on lap one.

[40] On 14–16 December Grosjean won the Race of Champions after a Grand Final victory over Le Mans legend Tom Kristensen at the Rajamangala Stadium in Bangkok.

[41] The day before Grosjean finished in second place in the Nations' Cup event along with his teammate Sébastien Ogier in the French team, after defeat by Germany's Sebastian Vettel and Michael Schumacher.

At the Hungarian Grand Prix Grosjean qualified 3rd on the grid but finished the race in 6th position after receiving a drive-through penalty for crossing the white line as he overtook Felipe Massa.

But in the race, his pace improved and he finished 8th, despite making contact with Pastor Maldonado in the opening laps and a mistake in the pits, both of which cost him some time.

In Monaco, Grosjean was on for his fourth consecutive points finish, despite a grid penalty for a gearbox change, but he was hit by Max Verstappen while battling for position.

Near the end of the race, he was under pressure from Maldonado, who had closed the gap to just over a second, but Grosjean managed to retain his 7th position to the finish and scored points for the first time since Belgium.

Grosjean was disqualified from the Italian Grand Prix after the floor of his car was found to be illegal, taking away a 6th-place finish; although the team appealed this, the decision was upheld.

In Singapore, Grosjean tagged George Russell during an overtake attempt, damaging his front wing and causing the Williams driver to crash into a wall.

In Brazil, Grosjean was running in 7th place late in the race behind Pierre Gasly and ahead of Carlos Sainz Jr., before issues with his car dropped him back to 14th by the finish line (13th after a penalty for Nico Hülkenberg).

[66] In what would be his final race, Grosjean suffered a serious crash in the 2020 Bahrain Grand Prix on the first lap in which his Haas VF-20 made contact with the AlphaTauri AT01 of Daniil Kvyat, and hit the barrier at high speed, splitting the car in half, releasing the fuel and causing a significant fire.

[68] He was able to exit the car unaided after 28 seconds, and was helped away from the crash scene by Alan van der Merwe and Ian Roberts, with minor burn injuries to his hands and ankles before being airlifted to a nearby military hospital.

[70] The halo head-protective device, introduced in Formula One in 2018, was credited with saving his life: it sheltered Grosjean's head and body from coming into contact with the barrier upon collision.

[94][95] Grosjean's performances were so strong that despite his partial schedule he was nearly able to outscore McLaughlin for the Rookie of the Year award heading into the final race at Long Beach.

2005  N. Rosberg 2006  L. Hamilton 2007  T. Glock 2008  G. Pantano 2009  N. Hülkenberg 2010  P. Maldonado 2011  R. Grosjean 2012  D. Valsecchi 2013  F. Leimer 2014  J. Palmer 2015  S. Vandoorne 2016  P. Gasly 2017  C. Leclerc 2018  G. Russell 2019  N. de Vries 2020  M. Schumacher 2021  O. Piastri 2022  F. Drugovich 2023  T. Pourchaire 2024  G. Bortoleto