He is an astronomer at the Steward Observatory of the college of science and professor in the James C. Wyant College of Optical Sciences,[1] both of The University of Arizona.

Guyon was awarded a MacArthur Fellowship "Genius Grant" in 2012.

[2] Guyon designs telescopes and other astronomical instrumentation that aid in the search for exoplanets planets outside the Solar System.

Guyon developed the PANOPTES project,[4] a citizen science project that aims to make it easy for anyone to build a low cost, robotic telescope that can be used to detect transiting exoplanets.

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