It is located at the intersection of Broad Street and Olney Avenue in the Logan neighborhood of Northwest Philadelphia.

It is a major bus terminal as well as the last subway stop on the Broad Street Line before the Fern Rock Transportation Center terminus.

Olney Transportation Center is located near Einstein Medical Center Philadelphia, La Salle University, Central High School, and the Philadelphia High School for Girls.

It is the second-most traveled terminal or transportation center in SEPTA's organization.

It also served as a trolley terminal until January 11, 1986 for Ogontz Avenue's Route 6, and was near Sigler Travel, a former Greyhound Lines bus station.