Each episode, Ward interviews an expert from a distinct scientific field (somnology, bryology, philematology, etc.).

[3][4][5] When recording the episodes, Ward aims to avoid "expert sound bites" in favor of a more conversational tone, and she cuts in segments to explain concepts that her guests introduce.

[2] Further inspiration built when a visit to the Natural History Museum of Los Angeles County in 2013 led into a weekly volunteer shift and a career change into science communications for Ward.

[2] In July 2021, Ologies began releasing shortened versions of classic episodes called "Smologies."

Edited specifically for classrooms, Smologies episodes run roughly 20 minutes, and do not have profanity.