The company was founded in 1987 by Marc Coucke and Yvan Vindevogel, both former pharmacy students at the Ghent University.

Omega Pharmaa was initially listed as a Naamloze vennootschap on the Euronext Brussels and used to be part of the BEL20 index until late 2011 when Coucke (through his investment company Couckinvest) and private equity firm Waterland took the company private once again.

[3] Omega Pharma was officially acquired by Perrigo with effect from 31 March 2015.

At the annual shareholders meeting of Omega Pharma held on 6 June 2006, it was announced that the company's professional health division would operate under the name of Arseus.

The legal structure of the entities in this division has been largely prepared in the meantime, so that the project to make Arseus an autonomous company is on schedule.